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Beta diversity: Jaccard, Bray-Curtis, NMDS, PCoA and PERMANOVA

Beta diversity: Jaccard, Bray-Curtis, NMDS, PCoA and PERMANOVA

by Biostatsquid | Feb 21, 2026 | Learning, Statistics

How different are communities from each other? Beta diversity easily explained! If you’ve ever hiked from a dense forest into an open grassland, you’ve probably noticed how dramatically the plants, insects, and animals can change within just a few miles. This...
Hill numbers and diversity profiles simply explained

Hill numbers and diversity profiles simply explained

by Biostatsquid | Feb 14, 2026 | Learning, Statistics

Exploring Hill numbers to compare the diversity across communities Whether you are analyzing a rainforest ecosystem, a human gut microbiome, or a B-cell receptor (BCR) repertoire, the fundamental challenge is the same: How do we accurately measure the diversity within...

Diversity metrics simply explained: Shannon, Simpson, Chao1

by Biostatsquid | Feb 14, 2026 | Learning, Statistics

Exploring alpha diversity indices and how to interpret them: Shannon, Simpson, Gini, Chao1 and more! Whether you are analyzing a rainforest ecosystem, a human gut microbiome, or a B-cell receptor (BCR) repertoire, the fundamental challenge is the same: How do we...
Which is the best scRNAseq integration method?

Which is the best scRNAseq integration method?

by Biostatsquid | Dec 14, 2025 | Learning, scRNAseq

Comparing top integration methods for scRNAseq data When we want to combine multiple scRNA-seq datasets to answer bigger questions, we encounter batch effects – unwanted technical variations that arise from differences in how the experiments were performed....
Integration methods in scRNAseq: easily explained!

Integration methods in scRNAseq: easily explained!

by Biostatsquid | Nov 30, 2025 | Learning, scRNAseq

An overview of the most popular integration methods for single-cell data Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of biology by allowing us to measure gene expression in individual cells rather than bulk tissue samples. This...
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Recent posts

  • Beta diversity: Jaccard, Bray-Curtis, NMDS, PCoA and PERMANOVA
  • Hill numbers and diversity profiles simply explained
  • Diversity metrics simply explained: Shannon, Simpson, Chao1
  • Which is the best scRNAseq integration method?
  • Integration methods in scRNAseq: easily explained!
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      All original blog posts, articles, and written content by Laura Twomey are licensed under Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Third-party images, photographs, and external materials are excluded and remain under their original copyright.